SNPeffect is a database of human non-synonymous coding SNPs (nsSNPs) mapping phenotypic effects of allelic variation in human genes. SNPeffect contains 31 659 nsSNPs from 12 480 human proteins. The current release of SNPeffect incorporates data on protein stability, integrity of functional sites, protein phosphorylation and glycosylation, subcellular localization, protein turnover rates, protein aggregation, amyloidosis and chaperone interaction. The SNPeffect software allows to analyse the effect of coding, non-synonymous SNPs on 3 categories of functional and physico-chemical properties of the affected proteins. SNPeffect uses computational tools to predict the effect caused by the mutations on the physico-chemical and biological properties of the affected proteins. It tries to pinpoint the exact effect of a mutation to a specific structural, physico-chemical or biological property.
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